Sinetrol® is a patented weight loss ingredient*, formulated from natural Mediterranean citrus.
Orange and grapefruit extracts are selected to create a synergy of bioactive polyphenols targeting body-weight management benefits.

Lipolysis is a catabolic process leading to the breakdown of triglycerides stored in fat cells (adipocytes), releasing free fatty acids (FFAs) and glycerol.

The action of Sinetrol® relies on its unique mechanism of action: the Fat Shredding Technology®. The active compounds of Sinetrol® help stimulate lipolysis through the inhibition of phosphodiesterase-4, the enzyme that catalyzes the hydrolysis of cyclic adenosine monophosphate (cAMP). Higher cAMP levels lead to an increased rate of triglyceride breakdown which naturally enhances the release of free fatty acids from the fat cells.

This is how the total fat mass of the subjects decreases.


Three clinical studies were conducted to investigate the benefits of Sinetrol® on body composition. With results from more than 190 subjects, this natural fat shredder is a proven and safe solution for helping to rid the body of the excess fat mass.

Following a prospective placebo-controlled clinical study on 20 subjects (1), a second clinical study was performed with 95 overweight subjects who consumed a normal diet and limited physical activity to 30 mins per week, over 3 months (2).

Sinetrol® helped to enhance body composition*:

Proven fat loss**: supplemented subjects dropped an average 10% of their abdominal fat mass

Waist and hip circumferences were each reduced by an average 5 cm

A third clinical study was recently conducted on 77 overweight and obese subjects. Sinetrol® confirms its benefits over 4 months*:

Subjects dropped an average 63% of their excess of body fat mass, as measured by the gold-stand technology DXA (Dual energy X-ray Absorptiometry)

Supplementation led to an increase of resting energy expenditure by 180kcal/day

Not only subjects lost weight but they also significantly gained lean mass, which contributed to a healthier body composition

Dallas C. et al.; Phytomedecine; 2008, 15: 783-792

Dallas C. et al.; Phytother. Res.; 2014, 28(2): 212-218

*These statements have not been evaluated by the Food and Drug Administration.

**This product is not intended to diagnose, treat, cure or prevent any disease.

Before participating in any diet or exercise program, please consult your physician


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Clinically investigated

3 proprietaries clinical trials
Double-blind, randomized, placebo-controlled & published studies

Demonstrated mechanism of action

Unique mechanism of action
Synergy of polyphenols

Healthier body composition

Body shape improvement
combined with an improved
lean-to-fat mass ratio